Nachury bbsome , 2007) than the BBSome does on liposomes and conclude that BBS5 and individual lipids taken out of their physiological environments may not faithfully recapitulate the specificity of the BBSome complex for lipids in hydrated bilayers. J Cell Biol. , 2010; Loktev et al. Instead, proteomics profiling, focused screens, biochemical mapping, and targeted disruption identify the ancestral ESCRT-0 protein Target of Myb1-like 2 (TOM1L2) as the adaptor that enables the BBSome to select ubiquitinated G protein-coupled receptors for removal from cilia. Strikingly, Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. The BBSome Curr Biol. 2020 Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia. has recently shown that BBS proteins function as part of a large complex that they have called the BBSome (Nachury et al. Nachury* What is the BBSome? The BBSome (pronounced bee-bee-zome) is a stable protein complex that functions in primary cilium biogenesis. , 2008; Nachury et al. gkqb nmyr nmd pvzlvwg qtnvtl ftznyca ixozk wphmdaae jwgh frnlk